Measurement of C reactive protein concentration in myocardial ischemia and infarction

Abstract

 
Background: Myocardial ischemia and infarction represent significant health concerns. 
Inflammation plays a crucial role in the pathophysiology of these conditions. The elevation of 
CRP levels, an acute-phase protein, signifies the inflammatory status and has been associated 
with the severity and prognosis of myocardial damage. Measuring C-reactive protein (CRP) 
concentration in myocardial ischemia and infarction has garnered significant attention due to 
its potential role as a biomarker for cardiovascular risk stratification. 
Patients and Methods: Subjects for the measurement of CRP concentration in myocardial 
ischemia and infarction include patients who present with symptoms of acute chest pain, such 
as angina pectoris or myocardial infarction. Blood samples are typically drawn on admission to 
the hospital and at various time intervals throughout hospitalization to measure CRP 
concentration. CRP concentration is one of several markers that are used to diagnose acute 
myocardial infarction, along with troponin levels, electrocardiography, and clinical symptoms 
Patients presenting with chest pain, suggestive of acute myocardial infarction or unstable 
angina. The study aimed to evaluate the diagnostic value of high-sensitivity crp (hs-crp) testing 
in this population, as well as the prognostic value of crp concentration in predicting adverse 
cardiovascular events. The study included 200 patients with chest pain and high sensitive crp 
concentration 
Result: This cross-sectional study included 200 patients who suggestive of acute myocardial 
infarction or unstable angina. 53% of included patients was diagnosed with myocardial 
ischemia and infraction and 47% was diagnosed with angina. The median age of included 
patients was 55 years old. The patients with MI were older than patients with angina (p=0.005). 
64% of included patients were male. There was statistically significant difference between both 
groups regarding age, sex and job occupations. There is marked elevation in crp level in old 
patient. the present study observed elevated levels of CKMB in patients experiencing acute MI 
compared to those with chronic or subacute MI 
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Conclusion: In conclusion, this study provided compelling evidence supporting the utility of 
C-reactive protein (CRP) as a biomarker for myocardial ischemia and infarction. The findings 
demonstrate a significant elevation in CRP levels among patients with myocardial infarction 
compared to those with angina. This aligned with previous research underscoring the role of 
CRP as an indicator of inflammation intricately linked with atherosclerotic disease progression 
and adverse cardiovascular outcomes. this study underscored CRP's utility as a predictor and 
prognosticator of myocardial infarction, independently or in conjunction with other biomarkers. 
It substantiated the role of inflammatory processes in MI pathogenesis and the need to 
incorporate CRP evaluation in the diagnosis and risk stratification of patients with suspected 
acute coronary events