Correlation of D dimer and coagulopathy among Yemeni patients with compensated and decompensated Liver disease and cirrhosis.

Abstract

Background: The liver is the largest organ in the body, Chronic liver disease consists of chronic hepatitis and cirrhotic hepatic. The liver has a cardinal role in the haemostatic system. Liver synthesizes plasma proteins including many coagulation proteins e.g., Factor I, II, V, VII, VIII, IX, X, XI, XII, XIII, many natural anticoagulants like protein C & S. Chronic or acute liver diseases frequently have an intense impact on the haemostatic system Bleeding in liver disease could be due to decreased plasma levels of haemostatic proteins synthesized by the liver. It could also be due to thrombocytopenia, coagulopathy, enhanced fibrinolysis or portal hypertension. Recent studies have shown that patients with liver disease also develop deep venous thrombosis and pulmonary artery embolism at rates between 0.5%-1.9%